Nicotiana quadrivalvis, commonly known as Indian tobacco or Columbian tobacco, is an annual herb that is native to riparian zones, moist places in grasslands, and open woodlands in the western United States, particularly California. It can grow up to 7 feet in height, with lower leaf blades that are up to 6 inches long. The plant features an inflorescence of white, greenish, or purple-tinged tubular flowers that bloom from late spring to early fall. The flowers are modest in size but can be quite numerous, creating a delicate display.

Indian tobacco is valued for its historical and cultural significance rather than its ornamental qualities. It is not commonly cultivated in gardens but may be of interest to those looking to create a native plant garden or for educational purposes. In cultivation, it prefers moist, well-drained soils and can tolerate a range of light conditions from full sun to partial shade. While it is not known for being particularly problematic, it may be susceptible to common pests and diseases that affect other Nicotiana species. It is also important to note that all parts of the plant are toxic if ingested.CC BY-SA 4.0